Osmotic Wearable
Bolus Injector

Subcuject WBI

Low cost
Patient friendly
Pharma friendly

News: Phillips-Medisize
and Subcuject have
entered a collaboration

Technology

Utilizing a strong force of nature

For injection of larger pharmaceutical volumes subcutaneously, a low flow rate is needed in order for the tissue to absorb the volume injected. In order to achieve this, complex and expensive drive mechanisms with batteries and electronics are commonly used in larger volume, on-body injectors.

The Subcuject WBI utilizes forward osmosis technology to generate force. In simplified terms, two chambers of liquid are separated by a semipermeable membrane. Adding salt to one chamber draws in liquid from the other chamber and hydraulic/mechanical pressure for driving the plunger in the primary drug container is generated. Simple and at a low cost.

Osmosis is a basic and strong force of nature.

Pending patents cover core and peripheral functionality.

Low Cost

The Subcuject WBI only has few moving parts, resulting in inherent low cost of goods sold.

The CoGS is in the range of prefilled autoinjectors.

Device platform subcuject

Patient friendly device

The Subcuject WBI:

  • Prefilled, preloaded device
  • Invisible/automatic needle insertion and retraction
  • Thin needles
  • Small size and low weight (76 mm long/55 g for 3 ml device)
  • Noiseless in operation
  • No patient assembly or setting of the device
  • settings or patient assembly of part
  • Single use disposable
  • No electronics or batteries

Pharma company friendly

The Subcuject device:

  • Prefilled, preloaded device
  • Few moving parts
  • Manufacturing price in the range of prefilled autoinjectors
  • Drug shelf life not compromised – at cold storage
  • Glass cartridge and standard rubbers as primary packaging
  • Can inject high viscosities (at least 100 cP through a G27 needle)
  • Currently designed for 3 ml delivery volume with a 5 ml version soon available – can be designed for higher volumes
  • No patient assembly or setting of the device i.e. low risk of incorrect use
  • As environmentally acceptable for single use as a prefilled autoinjector

Development

The Subcuject WBI is ready for drug specific development programs

The current device is a 3 ml version

Next version of 5 ml is in advanced development

Can be designed for larger volumes

3 ml device

Collaboration with Phillips-Medisize

Subcuject has a close collaboration with Phillips-Medisize on development, manufacturing and commercialization of the Subcuject WBI

 

News and Media

About

Why

The Subcuject WBI enables gentle injection of larger and more viscous doses compared to auto autoinjectors – at low cost

Biological drugs take up a high number of pharma development pipeline programs. The advantage of biological drugs is the specific targeting. Biologics are being developed for a large number of illnesses.

Biologics have to be injected, and in order to reduce the inconvenience, many drugs are being developed for subcutaneous delivery (as opposed to intravenous administration).

Furthermore, a large number of biologics are being developed for less frequent injection (e.g. weekly or monthly), resulting in larger and more viscous drugs needing to be administered. In order to avoid patients having go to hospitals for injections, it is also of benefit to the patients and to the total cost of health care if injections can be done at home.

The Subcuject WBI is a low cost device that allows for self-administration of larger doses in an easy-to-use and gentle way. The device is a prefilled, small, ready-to-use and noiseless device that is affixed to the skin, activated by a single button press and discarded after use. Needle insertion and retraction is invisible to the patient.

History

Subcuject was founded in 2017 to develop the Subcuject WBI.

The company is privately held and is funded by the Danish venture funds VF Venture and Capnova as well as management and the Board of Directors.

Management

Jesper Roested

CEO
+45 2122 7772

20+ years experience in business development, management and venture financing within medtech and life sciences.

...
Read More
Jesper Roested

CEO

20+ years experience in business development, management and venture financing within medtech and life sciences. MSc. In Medical Electronics & Physics.
Previously Partner at VF Venture investing in- and development of medtech companies. CEO of DDD-Diagnostic (nuclear medicine scanners), multiple positions at Novo Nordisk (in drugs and devices) and McKinsey & Co.

Claus Schmidt Møller inventor, Founder and CTO

Claus Schmidt Møller

Inventor, Founder and CTO
+45 2773 6420

B. Sc. Mechanical Engineering. 20+ years of track record in innovation of drug delivery devices.

...
Read More
Claus Schmidt Møller inventor, Founder and CTO
Claus Schmidt Møller

Inventor, Founder and CTO

B. Sc. Mechanical Engineering. 20+ years of track record in innovation of drug delivery devices. Inventor of Novopen 4 & 5 and co-inventor of Flexpen and Flextouch for Novo Nordisk. Several inventions of various medical devices made for or licensed to major Pharma and drug delivery companies. Mentioned as inventor or co-inventor on 60+ patent families.

Jesper Roested

CEO

20+ years experience in business development, management and venture financing within medtech and life sciences. MSc. In Medical Electronics &

...
Read More
Jesper Roested

CEO

20+ years experience in business development, management and venture financing within medtech and life sciences. MSc. In Medical Electronics & Physics.
Previously Partner at VF Venture investing in- and development of medtech companies. CEO of DDD-Diagnostic (nuclear medicine scanners), multiple

Claus Schmidt Møller inventor, Founder and CTO

Claus Schmidt Møller

Inventor, Founder and CTO

B. Sc. Mechanical Engineering. 20+ years of track record in innovation of drug delivery devices. Inventor of Novopen 4 &

...
Read More
Claus Schmidt Møller inventor, Founder and CTO
Claus Schmidt Møller

Inventor, Founder and CTO

B. Sc. Mechanical Engineering. 20+ years of track record in innovation of drug delivery devices. Inventor of Novopen 4 & 5 and co-inventor of Flexpen and Flextouch for Novo Nordisk. Several inventions of various medical devices made for or licensed

Board of Directors

Lars Guldbæk Karlsen

Chairman of the Board

Former pharma executive and PhD in Chemical Engineering.
35 years of pharma management experience from Novo

...
Read More
Lars Guldbæk Karlsen

Chairman of the Board

Former pharma executive and PhD in Chemical Engineering.
35 years of pharma management experience from Novo Nordisk, hereof 17 years in SVP positions including global responsibility for project portfolio management, business development, device R&D, clinical drug development and quality including 10 years as SVP of Manufacturing Quality.
Nine years as Chairman of the Board at Møller & Devicon A/S (now part of Syntegon Technology), special machine manufacturer to the pharma industry.

Paul Jansen

Member of the board

Former Global Head of Medical Device Development for Sanofi. Professional Engineer with more than twenty-five years

...
Read More
Paul Jansen

Member of the board

Former Global Head of Medical Device Development for Sanofi. Professional Engineer with more than twenty-five years of experience in medical devices. Extensive experience in the design, development, manufacturing and lifecycle management of medical devices, including Lantus SoloStar. Active member of the International Standards Organisation and currently co-chair of TC84.

Morten Nielsen

Member of the board

Former CEO of Medicom Innovation partner (acquired by Philips Medisize) a leading innovation player within Drug

...
Read More
Morten Nielsen

Member of the board

Former CEO of Medicom Innovation partner (acquired by Philips Medisize) a leading innovation player within Drug Delivery device and Connected Health solutions. Previously also leading positions in i.a. PA Consulting Group (Management and Technology Consulting), DGM (notified body) and S&W Medico Teknik. More than 25 years of leadership and operational experience – predominantly within MedTech.

Tonni Bülow-Nielsen

Member of the Board

Partner in VF Venture, Teamleader for the Lifescience/Medtech team. Invest from seed- to late stage in

...
Read More
Tonni Bülow-Nielsen

Member of the Board

Partner in VF Venture, Teamleader for the Lifescience/Medtech team. Invest from seed- to late stage in MedTech and Industrial technology. Tonni has extensive global industry operational experience. Previous positions include being CEO of Nordic Medical Group A/S, President, ELA Medical (Canada & South America) and VP USA, a part of Sanofi, Global Marketing Director for St. Jude Medical (Los Angeles, USA, and Japan), BU Director for St. Jude Medical EEMEA (Brussels, Belgium), Country Manager for Guidant Nordic

Lars Stigel

Member of the Board

CEO of Capnova, a Danish pre-seed and seed investor. PhD. Since 1998 Lars has been involved

...
Read More
Lars Stigel

Member of the Board

CEO of Capnova, a Danish pre-seed and seed investor. PhD. Since 1998 Lars has been involved in starting and investing in around 140 new companies of which 50 are spin out’s from university and hospital research. Before 1998 he among other positions was in charge of the profiling of university research towards the industry and managed a governmental cross institutional environmental research program.

Claus Demant member of the board

Claus Demant

Co-founder and Member of the Board

E*MBA from SIMI, HD (A) from Copenhagen Business School. 25 years of experience in leadership, strategy

...
Read More
Claus Demant member of the board
Claus Demant

Co-founder and Member of the Board

E*MBA from SIMI, HD (A) from Copenhagen Business School. 25 years of experience in leadership, strategy and business development.
International experience from IT, Electronics and MedTech industry. Regional Leadership positions in Creative Labs and SVP position in Daymen Acquisition S.A

Lars Guldbæk Karlsen

Chairman of the Board

Former pharma executive and PhD in Chemical Engineering.
35 years of pharma management experience from Novo Nordisk, hereof 17 years

...
Read More
Lars Guldbæk Karlsen

Chairman of the Board

Former pharma executive and PhD in Chemical Engineering.
35 years of pharma management experience from Novo Nordisk, hereof 17 years in SVP positions including global responsibility for project portfolio management, business development, device R&D, clinical drug development and quality including 10 years as SVP of Manufacturing Quality.
Nine years as Chairman of the Board at Møller & Devicon A/S (now part of Syntegon Technology), special machine manufacturer to the pharma industry.

Paul Jansen

Member of the board

Former Global Head of Medical Device Development for Sanofi. Professional Engineer with more than twenty-five years of experience in medical

...
Read More
Paul Jansen

Member of the board

Former Global Head of Medical Device Development for Sanofi. Professional Engineer with more than twenty-five years of experience in medical devices. Extensive experience in the design, development, manufacturing and lifecycle management of medical devices, including Lantus SoloStar. Active member of the International Standards Organisation and currently co-chair of TC84.

Morten Nielsen

Member of the board

Former CEO of Medicom Innovation partner (acquired by Philips Medisize) a leading innovation player within Drug Delivery device and Connected

...
Read More
Morten Nielsen

Member of the board

Former CEO of Medicom Innovation partner (acquired by Philips Medisize) a leading innovation player within Drug Delivery device and Connected Health solutions. Previously also leading positions in i.a. PA Consulting Group (Management and Technology Consulting), DGM (notified body) and S&W Medico Teknik. More than 25 years of leadership and operational experience – predominantly within MedTech.

Tonni Bülow-Nielsen

Member of the Board

Partner in VF Venture, Teamleader for the Lifescience/Medtech team. Invest from seed- to late stage in MedTech and Industrial technology.

...
Read More
Tonni Bülow-Nielsen

Member of the Board

Partner in VF Venture, Teamleader for the Lifescience/Medtech team. Invest from seed- to late stage in MedTech and Industrial technology. Tonni has extensive global industry operational experience. Previous positions include being CEO of Nordic Medical Group A/S, President, ELA Medical (Canada & South America) and VP USA, a part of Sanofi, Global Marketing Director for St. Jude Medical (Los Angeles, USA, and Japan), BU Director for St. Jude Medical EEMEA (Brussels, Belgium), Country Manager for Guidant Nordic

Lars Stigel

Member of the Board

CEO of Capnova, a Danish pre-seed and seed investor. PhD. Since 1998 Lars has been involved in starting and investing

...
Read More
Lars Stigel

Member of the Board

CEO of Capnova, a Danish pre-seed and seed investor. PhD. Since 1998 Lars has been involved in starting and investing in around 140 new companies of which 50 are spin out’s from university and hospital research. Before 1998 he among other positions was in charge of the profiling of university research towards the industry and managed a governmental cross institutional environmental research program.

Claus Demant member of the board

Claus Demant

Co-founder and Member of the Board

E*MBA from SIMI, HD (A) from Copenhagen Business School. 25 years of experience in leadership, strategy and business development.
International

...
Read More
Claus Demant member of the board
Claus Demant

Co-founder and Member of the Board

E*MBA from SIMI, HD (A) from Copenhagen Business School. 25 years of experience in leadership, strategy and business development.
International experience from IT, Electronics and MedTech industry. Regional Leadership positions in Creative Labs and SVP position in Daymen Acquisition S.A

Contact

The Subcuject WBI is designed for drug/device combinations products, requiring combined development for the specific drug.

Please contact us for discussing your needs.

Jesper Roested

CEO
Phone: +45 2122 7772
jr@subcuject.com

Subcuject ApS

Nordre Strandvej 119, F1
DK-3150 Hellebaek
Denmark